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Police have reported that the collision took place at the junction near Victoria Place, Taunton.
There are also reports stating that an ambulance was called to the scene as one male has a suspected broken arm.
Police have advised that there will be traffic around this area and drivers should take care when travelling through.
A38 East Reach both ways busy but moving from A38 Chritchard Way to B3170 Silver Street.
Reports say that a bus and a car have been involved in a collision on East Reach, Taunton, near the White Hart pub.